Synthesis of heterocycles via aerobic oxidation

Synthesis of heterocycles via palladium-catalyzed carbonylations.

Synthesis of oxygen heterocycles via alkynyltungsten compounds*

This short review article covers some useful applications of alkynyltungsten compounds to the syntheses of complex lactones. Two types of cyclizations will be emphasized: (1) cycloalkenylation of tungsten-alkynol compounds with aldehydes to give α-alkylidene oxacarbeniums, further leading to α-alkylidene lactones and (2) intramolecular [3+2]-cycloaddition of epoxides to give bicyclic lactones. ...

Bioinspired aerobic oxidation of secondary amines and nitrogen heterocycles with a bifunctional quinone catalyst.

Copper amine oxidases are a family of enzymes with quinone cofactors that oxidize primary amines to aldehydes. The native mechanism proceeds via an iminoquinone intermediate that promotes high selectivity for reactions with primary amines, thereby constraining the scope of potential biomimetic synthetic applications. Here we report a novel bioinspired quinone catalyst system consisting of 1,10-...

Synthesis of α,β-unsaturated carbonyl compounds via a visible-light-promoted organocatalytic aerobic oxidation.

α,β-Unsaturated ketones and aldehydes have been synthesized from their corresponding silyl enol ethers in a straightforward protocol involving a visible-light promoted organocatalytic, aerobic oxidation reaction. A cheap organic dye was used catalytically in these reactions as the photosensitizer.

Synthesis of heterocycles via palladium-catalyzed oxidative addition.

Palladium-catalyzed processes have proven to be a powerful and useful tool for the synthesis of heterocycles. Palladium has found such wide utility because it affects an extraordinary number of very different reactions, including many carbon-carbon bond-forming reactions, under relatively mild reaction conditions. Furthermore, palladium can usually be used in only catalytic amounts and tolerate...